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KMID : 0365819710110010109
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Journal of Pusan Medical College
1971 Volume.11 No. 1 p.109 ~ p.128
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Studies of the Mechanism of Neutrophilia due to Glucocorticoid
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Abstract
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After the use of intravenous injections of prednisolone and cortisone in rabbits their plasma was removed and the plasma was injected into variously operated rabbits following which procedure the circulating pseudoeosinophil and lymphocyte counts were studied.
The following is a summary of the various important findings and conclusions which have been drawn from the data obtained.
1. Normal rabbits were injected with either prednisolone or cortisone and their blood counts were followed at regular set intervals. There appeared an increase of the pseudoeosinophil count, but there was no decrease in the lymphocyte count. It is speculated that there is a plasma factor produced following the injection of the cortisone or prednisolone that specifically causes a rise in the pseudoeosinophil count.
2. In bilaterally adrenalectomized rabbits the same experiment was carried out and in addition to a reduction in the ability of the animal to produce the plasma factor, it was felt that the produced plasma factor did not have its normal effect of causing its usual rise in the pseudoeosinophil count. 3. Following either splenectomy or cutting of the spinal cord, the rabbits were subjected to the injection of either prednisolone or cortisone and followed as in the above experiments. It was felt that following either of these procedures the rabbit could produce the plasma factor and could be stimulated to produce an increase of the pseudoeosinophils secondary to the plasma factor.
4. Lastly, it was suggested that when an increase of the neutrophil count is produced by adrenal gland hormones, the effect is meditated by way of the plasma factor that in turn stimulates the bone marrow to produce the rise in neutrophil count. It is, therefore, most likely that the mechanism of the neutrophilia induced by adrenocortical hormones is quite different from that of the lymphopenia due to the same hormones.
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